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Conclusions In summary, this study demonstrates the first evidence that exogenous GABA mitigates TS-like behavior in TS model rats by modulating harmful intestinal flora and striatal GABA-glutamate metabolism, central inflammatory state, and directly enhancing neuroprotective metabolites

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After the surgery the animals were maintained under a 12 hour light/12 hour dark cycle and were closely monitored and gently handled for 5 minutes per day, 5-6 days after the surgery was performed [2]

Studies in the model organism Caenorhabditis elegans have demonstrated that different FOXO isoformsparticularly DAF-16Aexert a significant influence on lifespan extension by activating or repressing specific genes such as gst-20 and srr-4, which either promote or inhibit longevity-associated mechanisms